Therapy Trends: Alzheimer's Disease - Breaking new ground in disease modification





  

Publication date: May 2012 |Format: PDF |Pages: 161  

 An incisive, dynamic analytical report that uses insight from the most influential key opinion leaders (KOLs) in Alzheimer’s disease (AD) to map the current treatment landscape and identify future trends.   

 

 

 

 Alzheimer’s Disease: Beta-amyloid light fades to leave development hole
By the end of 2012, the Alzheimer’s disease market will reach a pivotal stage with the release of Phase III results of disease-modifying therapies, and new research into biomarkers to aid early AD diagnosis. If positive, these results will  validate the beta amyloid approach, but if negative, it will represent a huge blow to Alzheimer’s research. Recent trends in the AD market also represent a clear shift in researchers’ approaches to detecting, treating and preventing AD.
 
 

‘Therapy Trends: Alzheimer’s Disease’ is compiled from exclusive, in-depth interviews with the world’s leading KOLs in AD. It identifies and analyses the major factors, advances and trends currently influencing the AD treatment landscape. The report focuses on late-stage pipeline products, and how these could modify future AD management.  

Drive your strategic decision-making with inside intelligence ‘Therapy Trends: Alzheimer’s Disease’ disseminates the critical opinions of KOLs, giving you greater insight to the latest AD market advances. This information includes:  

 •The most relevant factors driving the global AD market, allowing you to start planning your business strategies without delay
•First-hand feedback from the most influential AD KOLs, giving you the strategic head-start you need for informed market decision-making
•KOL consensus on the future AD treatment algorithm helping you identify the clinical evidence and potential use of new AD therapies
•KOL opinions on unmet needs and industry challenges allowing you to recognised and capitalise on possible commercial AD opportunities
•On-going AD report updates for 12 months providing you with fast KOL feedback on the significance of industry events within days of their occurrence.
 


Critical questions answered
FirstWord selected the KOLs for this Therapy Trends report based on their level of engagement and influence within the AD pharmaceutical industry, and their scientific standing. Our unique KOL scoring system identifies those thought-leaders with the greatest insight into how AD clinical research will shape the future market.
  

These KOLs provided answers to some critical questions regarding the global AD market:  

 •What do KOLs make of bapineuzumab’s failure and its impact on future developments?
•What are the current unmet needs and major challenges in AD treatment?
•What is the most promising late-stage pipeline therapy in disease-modifying development?
•Which existing first-line therapies for AD face generic erosion in the near future?
•Where could Eli Lilly’s solanezumab be positioned in the AD market?
•How could solanezumab’s different mechanism of action affect its use in AD?
•In what ways could brain imaging and biomarkers improve future AD disease management?
•How promising do KOLs think Baxter’s Gammagrad could be as a disease-modifying AD drug?
•When should potential disease-modifying drugs be started in AD patients?
•How do KOLs think pricing and safety will shape the uptake of new AD treatments?
•What clinical research trends do KOLs predict for future AD therapies?
 
 

Key Benefits   

•Understand the current trends driving and shaping global drug markets
•Analyse the commercial and clinical potential of major pipeline therapies
•Develop your strategies and resources based on KOL insight
•Identify the unmet needs and opportunities for disease management
•Evaluate the performance of companies with the most robust new product pipelines
•Recognise the key factors KOLs predict will drive future treatment trends.
For users with responsibilities in
•Business Development
•New Product Planning
•Market Research
•Strategic brand planning
•Forecasting and marketing professionals
•Medical Affairs
•Clinical Trials
•Relationship Management.
 
 

  

 

•Understand the current trends driving and shaping global drug markets •Analyse the commercial and clinical potential of major pipeline therapies
•Develop your strategies and resources based on KOL insight
•Identify the unmet needs and opportunities for disease management
•Evaluate the performance of companies with the most robust new product pipelines
•Recognise the key factors KOLs predict will drive future treatment trends.For users with responsibilities in
•Business Development
•New Product Planning
•Market Research
•Strategic brand planning
•Forecasting and marketing professionals
•Medical Affairs
•Clinical Trials
•Relationship Management.
 


Informed Intelligence 
 

•Exclusive feedback from KOL panels involving leading global experts in the treatment and diagnosis of major medical conditions
•Consensus ratings of therapeutic developments and events compiled from a collaborative online resource of more than 535,000 vetted physicians
•Live dispatches and critical industry information from a network of correspondents who attend over 125 medical conferences each year
•Over 2,000 peer-reviewed medical journals
•Over 450 pharmaceutical news sources.
Therapy Trends: Intelligence Two Ways
Therapy Trends Intelligence Reports are concise, focused, market intelligence studies. They identify and analyse recent and upcoming trends driving the development of current and late-stage pipeline products for specific medical therapy sectors. They also provide you with valuable insight on the potential commercial impact of upcoming drugs on the existing market landscape.  
 

 Therapy Trends Impact Assessments offer you on-going analytical updates on the impact of significant drug market events, within days of their occurrence.  

 

The deliverables  

 

  

 

  

 

  FirstWord’s ‘Therapy Trends: Alzheimer’s Disease’ is delivered to you in two complementary formats:  

Therapy Trends Intelligence Report: a concise, in-depth market intelligence research report that examines current and late-stage pipeline products. It identifies future trends in the clinical treatment and diagnosis of AD, and assesses the commercial impact on the AD market landscape.   

Therapy Trends Impact Assessments: dynamic analyst briefings that evaluate the impact of events in the AD pharmaceutical market over the next 12 months. These updates will be delivered to you within days of a significant event happening.   

Who should buy this report?  

This report will be of value to senior pharma directors and managers with responsibilities in the following areas:  

 •Business Development
•New Product Planning
•Market Research
•Strategic brand planning
•Forecasting and marketing professionals
•Medical Affairs
•Clinical Trials
 
 

   

 

 

 Executive Summary 

•Introduction 

•Methodology 

•Current Alzheimer’s disease marketplace
> Current treatment landscape
> Reimbursement of key Alzheimer’s disease brands
> Current therapies
> Aricept (donepezil; Eiasi/Pfizer) trends
> Exelon (rivastigmine; Novartis) trends
> Razadyne (galantamine; Johnson & Johnson/Shire) trends
> Namenda/Ebixa (memantine; Forest/Merz/Lundbeck) trends
> Current treatment algorithm
> Unmet needs in Alzheimer’s disease
> Late-stage disease-modifying therapies primarily target beta-amyloid
> Bapineuzumab (Johnson & Johnson/Pfizer) trends
> Solanezumab (LY2062430, Eli Lilly) trends
> Gammagard (immune globulin IV [human], Baxter) trends
> Future prescribing trends
 

   

•Future developments in Alzheimer’s disease
> Clear definition of disease-modifying is required
> Improved understanding of underlying disease etiology
> Targets beyond beta-amyloid
> Gene therapy as a treatment option
> Enrolment of trials will be more important for success
> Identification of patients earlier in disease course for intervention
> Development of biomarkers will aid diagnosis and treatment
 
 

•FirstWord Alzheimer’s disease news analysis
> Positive Alzheimer’s disease key news events
> Negative Alzheimer’s disease key news events
 
 

•Appendix 1
> KOL biographies
 
 

•Appendix 2
> Alzheimer’s disease news article links