Date Published 
June 2015

Page Count 
208

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Ocular Disorders: Rising Therapeutics, Technologies, and Devices - Table of Contents

Executive Summary 

CHAPTER 1: Age-Related Macular Degeneration 

Wet AMD 

Dry AMD 

CHAPTER 2: Therapeutic Efficacy 

Anti-VEGF therapies 

  • Pegaptanib
  • Bevacizumab
  • Ranibizumab
  • VEGF Trap-EYE
 

CHAPTER 3: Oraya Therapeutics 

Radiotherapy platform 

  • Automatic Positioning System (APS)
  • I-Guide
  • System software
 

Radiation dosing 

Potential complications and risk factors 

Competitive advantage 

Challenges and areas of improvement 

Future expectations 

Interview with Jim Taylor 

  • Radiation therapy
  • Competitive advantage
  • Challenges encountered
  • Areas of improvement
  • Future expectations
 

CHAPTER 4: VisionCare Ophthalmic Technologies 

Company background 

Telescope technology 

Complications and challenges 

Interview with Reena Mishra 

  • Company background
  • Telescope technology
  • Competitive advantage
  • Complications and challenges
 

CHAPTER 5: Omeros 

Company background 

PharmacoSurgery platform 

Pipeline 

Competitive advantage 

Challenges encountered 

Validation 

Future expectations 

Interview with Greg Demopulos 

  • Company background
  • PharmacoSurgery platform
  • OMS302
  • Competitive advantage
  • Challenges encountered
  • Validation procedure
  • Future expectations 
 

CHAPTER 6: Kala Pharmaceuticals 

Company background 

Mucosal penetrating products (MPP) 

Competitive advantage 

Future endeavors 

Interview with Kim Brazzell 

  • Company background
  • Mucosal penetrating products (MPP)
  • Challenges encountered
  • Competitive advantage
  • Future endeavor 
 

CHAPTER 7: Platforms and Products 

CHAPTER 8: Survey of Ocular Industry 

Areas of development 

Promising targets and therapies 

Challenges encountered 

CHAPTER 9: Clinical Trials and Pipeline Data 

CHAPTER 10

Company Profiles 79

13therapeutics, Inc. 79

2C Tech Corporation, Inc. 79

AbbVie Inc. 80

Abdi Ìbrahim Ìlac Sanayi ve Tic A.S. (Abdi Ibrahim) 80

AC Immune SA 80

ACADIA Pharmaceuticals 80

Aciex Therapeutics, Inc. 81

Aciont Inc. 81

Acorn Biomedical, Inc. 81

Actavis hf. 82

Acucela Inc. 82

Adamed Sp. z o.o. 82

Adenovir Pharma AB 83

AdeTherapeutics Inc. 83

Aerie Pharmaceuticals, Inc. 83

Aerpio Therapeutics, Inc. 84

Akebia Therapeutics, Inc. 84

Akorn Pharmaceuticals, Inc. 84

Alcon Laboratories, Inc. 85

Alexion Pharmaceuticals, Inc. Translational Medicine Center 85

Alimera Sciences, Inc. 85

Alkeus Pharmaceuticals, Inc. 86

Allegro Ophthalmics LLC 86

Allergan, Inc. 86

Allergan S.A.U. 87

Altacor 87

Altheos, Inc. 87

Amakem Therapeutics NV 88

AmorChem L.P. 88

AngioLab, Inc. 88

Ångstrom Pharmaceuticals, Inc. 89

Apellis Pharmaceuticals, Inc. 89

Apitope International NV 89

Applied Genetic Technologies Corp. (AGTC) 90

ArcticDx, Inc. 90

Argos Therapeutics, Inc. 90

AriBio 91

Ascendis Pharma A/S 91

AsclepiX Therapeutics, LLC 91

Asklepios BioPharmaceutical, Inc. 92

Aspireo Pharmaceuticals Limited 92

Aus Bio Limited 92

Auven Therapeutics Management L.L.L.P. 93

Avalanche Biotechnologies, Inc. 93

Avedro 93

Axxam S.p.A. 94

Bach Pharma, Inc. 94

Bausch & Lomb 94

Bausch & Lomb Canada Inc. 95

Bayer Yakuhin, Ltd. 95

BCN Peptides S.A. 95

Beijing Northland Biotech Co., Ltd. 96

Beijing Tide Pharmaceutical Co., Ltd. 96

Benitec Biopharma Ltd. 96

Betastem Therapeutics, Inc. 97

Bicycle Therapeutics Limited 97

Binex Co., Ltd. 97

Biocodex S.A. 98

Biocycive 98

BioDiem Ltd 98

Bioftalmik 99

BioMotiv LLC 99

Bionure 99

Biophytis 100

Bloomage BioTechnology Corporation Limited 100

BluBio (Yantai) Biopharmaceutical Co., Ltd. 100

Bohus BioTech AB 101

Boston Children’s Hospital 101

Brill Pharma 101

Calista Therapeutics, Inc. 102

Can-Fite BioPharma Ltd. 102

Catalyst Biosciences 102

Cell Cure Neurosciences Ltd 103

CellSeed Inc. 103

Celsus Therapeutics plc 103

Celtaxsys, Inc. 103

Charlesson LLC 104

Chia Tai Tianquing Pharmaceutical Group Co., Ltd 104

China Resources Zizhu Pharmaceutical Co., Ltd 104

Circadian Technologies Limited 105

Clayton Biotechnologies, Inc. 105

Clearside Biomedical, Inc. 105

Compugen Ltd. 106

Corena Therapeutics SARL 106

D.Western Therapeutics Institute, Inc. 107

Dalian Innobioactives Co., Ltd. 107

Diaxonhit Therapeutics 107

DIOPTIC Laboratories, Inc. 107

DNAVEC Corporation 108

Dompé s.p.a. 108

Dong-A ST 108

Eleven Biotherapeutics, Inc. 109

Eli Lilly and Company 109

Emcure Pharmaceuticals Ltd. 109

Encore Vision, Inc. 109

Envisia Therapeutics™, Inc. 110

Enzo Biochem, Inc. 110

Eos Neuroscience, Inc. 110

EryDel S.p.A. 111

ESBATech, a Novartis company 111

Essex Bio-Technology Limited 111

Esteve 111

Eupraxia Pharmaceuticals Inc. 112

Europharm Laboratoires Co. Ltd. 112

Evonik Corporation 112

Exonate 113

EyeGate Pharmaceuticals, Inc. 113

EyeGene, Inc. 113

EyeTechCare SA 113

Eye Therapies LLC 114

Eyevensys SA 114

F. Hoffmann-La Roche AG 114

Farmaprojects S.A.U. 115

Farmigea S.p.A. 115

FirstString Research, Inc. 115

Foamix Pharmaceuticals Ltd. 115

Fondazione Telethon 116

ForSight Labs, LLC 116

ForSight VISION5, Inc. 116

Freedom Meditech, Inc. 117

La Fundación General de la Universidad de Valladolid FGUVa 117

Galecto Biotech AB 117

Genable Technologies Ltd. 117

Genentech, Inc. 118

Gene Signal International SA 118

GenSight Biologics 118

Genzyme® Corporation 119

GlaxoSmithKline plc 119

GrayBug® LLC 119

Griffin Discoveries BV 120

G-treeBNT Co., Ltd. 120

HanAll BioPharma Co. Ltd. 120

Hanlim Pharmaceuticals Inc. 120

Harmonic Pharma 121

Healios KK 121

Hemera Biosciences, Inc. 121

Herantis Pharma plc 122

High Point Pharmaceuticals, LLC (formerly TransTech Pharma, Inc.) 122

Horus Pharma 122

Hubei Kangzheng Pharmaceutical Co., Ltd. 122

Hyundai Pharm. Ind. Co., Ltd. 123

iCo Therapeutics Inc. 123

Iconic Therapeutics, Inc. 123

Ilsung Pharmaceuticals Co. Ltd. 124

Imagen Biotech, Inc. 124

Immco Diagnostics, Inc. 124

Immunservice GmbH 124

Implandata Ophthalmic Products GmbH 125

Imprimis Pharmaceuticals, Inc. 125

Inflamalps SA 125

InFlectis BioScience 126

InnoCore Technologies BV 126

InnoPharma, Inc. 126

Innovent Biologics, Inc. 127

Inotek Pharmaceuticals Corporation 127

InSite Vision Incorporated 128

Intellect Neurosciences, Inc. 128

InteRNA Technologies B.V. 128

International Stem Cell Corporation 128

Intrexon Corporation 129

ipal GmbH 129

Isis Pharmaceuticals, Inc. 129

iSTAR Medical SA 130

Jade Therapeutics, Inc. 130

Jiangsu Farever Pharmaceutical Co., Ltd. 130

Jiangsu T-mab BioPharma 130

Kala Pharmaceuticals, Inc. 131

KalVista Pharmaceuticals Ltd. 131

Kangmei Pharmaceutical Co., Ltd. 131

Korea Research Institute of Chemical Technology 132

Kowa Company, Ltd. 132

Kunshan RiboQuark Pharmaceutical Technology Co. Ltd. 132

Kytogenics Pharmaceuticals, Inc. 132

Laboratoires Genévrier 133

Laboratoires Théa 133

Laboratorios SALVAT S.A. 133

Laboratorios Sophia S.A. de C.V. 133

Lacerta Bio Inc. 133

LambdaVision, Inc. 134

Lee’s Pharmaceutical Holdings Ltd. 134

Lexicon Pharmaceuticals, Inc. 134

Livwel Therapeutics, Inc. 135

Lotus Innovative Health, Ltd. 135

Lpath Incorporated 135

MacuCLEAR, Inc. 135

MacuLogix, Inc. 136

Mati Therapeutics, Inc. 136

Merck Serono (EMD Serono) 136

Mesoblast Limited 137

Meta-IQ 137

Mimetogen Pharmaceuticals, Inc. 137

Mitsubishi Tanabe Pharma Corporation 137

Molecular Partners AG 138

Montefarmaco OTC S.p.A. 138

Moorfields Pharmaceuticals 138

Mystic Pharmaceuticals 138

Myungmoon Pharm. Co., Ltd. 139

Nanomerics 139

Nano Retina, Inc. 139

NanoVector srl 140

NanoViricides, Inc. 140

Nektar Therapeutics 140

NEMUS Bioscience, Inc. 140

Neothetics™, Inc. 141

Neuroptis Biotech 141

Neuroscienze PharmaNess S.c.a.r.L. 141

Neurotech Pharmaceuticals, Inc. 141

Nexus Pharamaceuticals, Inc. 142

NicOx Research Institute SRL 142

NicOx S.A. 142

NightstaRx Ltd. 142

NovaBay Pharmaceuticals, Inc. 143

Novaliq GmbH 143

NovaMedica LLC 143

Novartis International AG 144

Novartis Ophthalmics AG 144

NovelMed Therapeutics, Inc. 144

Ocata Therapeutics, Inc. 145

Ocugen, Inc. 145

Oculeve 145

Oculis ehf 146

Ogenx Therapeutics Corporation, Inc. 146

Ohr Pharmaceutical Inc. 146

Omeros Corporation 146

OMIDA AG 147

ONL Therapeutics LLC 147

OphthaliX, Inc. 147

OphthalmoPharma Ltd. 147

Ophthotech Corp. 148

Opocrin S.p.A. 148

Opthea Pty Ltd 148

Ora Bio Ltd. 149

Oraya Therapeutics, Inc. 149

Otsuka Pharmaceutical Europe Ltd 149

Oxford BioMedica plc 149

OxiGENE, Inc. 150

Palobiofarma S.L 150

Panoptes Pharma GmbH 150

PanOptica, Inc. 150

Parion Sciences 151

PDL BioPharma, Inc. 151

Perrigo Company plc 151

Pfenex Inc. 152

Pfizer 152

Pharma Two B Ltd. 153

Physica Pharma 153

Pieris Pharmaceuticals, Inc. 153

Pierre Fabre SA 154

PIQUR Therapeutics AG 154

Pixium Vision SA 154

PolyActiva Pty Ltd. 155

Potentia Pharmaceuticals, Inc. 155

Present Value Ltd 155

Promedior, Inc. 155

ProRetina Therapeutics, S.L. 156

Provectus Biopharmaceuticals, Inc. 156

pSivida Corp. 156

QLT Inc 157

Quark Pharmaceuticals, Inc. 157

Rapid Pathogen Screening, Inc. 157

Reata Pharmaceuticals, Inc. 158

Regeneron Pharmaceuticals 158

RegeneRx Biopharmaceuticals, Inc. 158

REGENXBIO Inc. 159

ReNeuron Group plc 159

Resolvyx Pharmaceuticals, Inc. 159

RestorGenex Corporation 160

RetroSense Therapeutics LLC 160

Rigel Pharmaceuticals, Inc. 160

River Vision Development Corp. 161

Roche Diagnostics GmbH 161

Roche SAS 161

R-Tech Ueno, Ltd. 161

RXi Pharmaceuticals Corporation 161

Sam Chun Dang Pharm. Co., Ltd 162

Samil Pharm. Co., Ltd. 162

SanBio, Inc. 162

Sanitas AB 162

Sanofi S.A. 163

Santen Pharmaceutical Co., Ltd. 163

Santhera Pharmaceuticals 163

SATT Lutech 164

SCYNEXIS, Inc. 164

Senju Pharmaceutical Co., Ltd 164

Shire plc 165

SIFI SpA 165

Silvanols 165

Sirnaomics, Inc. 166

SK Biopharmaceuticals 166

Solx, Inc. 166

Spark Therapeutics, Inc. 167

Specialised Therapeutics Australia Pty Ltd 167

Starpharma 167

Stealth Peptides International (Shanghai) Inc. 168

Stelic Institute & Co., Inc. 168

Stelis Biopharma Pvt. Ltd. 168

StemCells, Inc. 169

Strathclyde University, Health Technologies 169

Streuli Pharma AG 169

Strides Arcolab Ltd. 169

Sucampo Pharmaceuticals, Inc. 170

Sun Pharma Advanced Research Company (SPARC) Ltd. 170

Suzhou Sirnaomics Biopharmaceuticals Co. Ltd. 170

Sylentis S.A. 170

SynCore Biotechnology Co., Ltd 170

Synovo GmbH 171

Tacere Therapeutics, Inc. 171

Tactical Therapeutics, Inc. 171

Taejoon Pharm Co., Ltd. 172

Taiwan Liposome Company Ltd. 172

TearScience®, Inc. 172

Teijin Pharma Limited 172

ThromboGenics NV 173

TLC Biopharmaceuticals B.V. 173

TOA EIYO LTD. 173

TopiVert Ltd. 173

TRACON Pharmaceuticals, Inc. 174

TRB Chemedica International S.A. 174

TxCell 174

UNIMED PHARMA, spol. s r.o. 175

UNITHER Pharmaceuticals 175

University of Nottingham 175

University of Santiago de Compostela 175

Valeant Pharmaceuticals International, Inc. 176

Valentia Biopharma S.L. 176

Venture Life Ltd 176

Vibalogics GmbH 177

VisionCare Ophthalmic Technologies. Inc. 177

VISIOTACT Pharma 177

Wellstat Ophthalmics Corporation 177

X-BODY Biosciences, Inc. 178

Xcovery Vision 178

Xediton Pharmaceuticals Inc. 178

XOMA Corporation 179

Youcare Pharmaceutical Group Co., Ltd. 179

ZeaVision®, LLC 179

Ziarco 179

References