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SECTION 1
CGH Highlights Copy Number Differences
Eclectic Applications
An Overview of the Methodology
The Evolution of CGH
SECTION 2
The Scope of CGH Technology
Methods
Steps
DNA Isolation and Preparation
Amplification
Labeling
Hybridization on a Microarray
Scanning and Analysis
Limitations and Challenges
Underlying Assumptions
Copy Number Polymorphisms (CNPs)
Distinguishing Loss of Heterozygosity
Alternatives to CGH
SECTION 3
Applications of CGH
Reproduction
Assisted Reproduction Technologies
Inherited Developmental Disorders
Mental Retardation
Multifactorial Disorders
Cancer
Evolution
SECTION 4
Expert Interviews
Daniel Pinkel, PhD, University of California, San Francisco,
Comprehensive Cancer Center
Wendy Price, PhD, Invitrogen Corp.
Peggy Eis, NimbleGen Systems Inc.
SECTION 5
Selected Company Profiles
Affymetrix
Agilent
Invitrogen Corp.
Molecular Devices Corp.
NimbleGen Systems Inc.
Signature Genomic Labs, LLC
APPENDIX
CHI Advances: Comparative Genomic Hybridization Survey, August 2006
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