High-Content Analysis: Technologies, Applications, Market Analysis

By James Kling and Richard Fisler

Table of Contents

Chapter 1
INTRODUCTION
1.1. HCA Defined
1.2. Similarities Between HCA and high-throughput screening
1.3. Overlap Between HCA and HTS
SIDEBAR:
One Group’s Experience

Chapter 2
HCA: CURRENT STATE
2.1. Introduction
2.2. Use Categories
Primary Screening
Secondary Screening and Toxicology
SIDEBAR:
Kinetic Analyses vs. Fixed-Cell Analyses
2.3. Live-Cell Analysis
2.4. Common Applications
2.5. Common Assays
2.6. Imaging Consideration
2.7. Confocal Instruments
2.8. New Developments
Assays and Kits
2.9. Software Challenges
3D and 4D Image Analysis
2.10. A Third-Party Software Provider’s Perspective
2.11. Data Standardization

Chapter 3
COMPANIES, TRENDS, AND MARKETS
3.1. Leaders
3.2. Trends
3.3. HCA vs. HTS
3.4. Barriers to Entry
3.5. Technology Wishes

Chapter 4
HCA MARKET ANALYSIS
4.1. Main Drivers and Barriers
4.2. Position of Dominant Players
An Emerging Market for Kits and Assays
4.3. Analysis of Total Cost of Ownership
4.4. Analysis of HCA Applications
Emergence of the Academic Market
4.5. Market Dynamics: Big Fish Eating Little Fish

REFERENCES
COMPANY INDEX WITH WEB ADDRESSES
EXPERTS INTERVIEWED FOR THIS REPORT
Andrea Chow, vice president of microfluidics R&D, Caliper Life Sciences
Cathy Howat, marketing director for InCell Analyzer in Europe, GE Healthcare
Mark Collins, marketing manager, cellular imaging and analysis business, Cellomics
Peter O'Brien, University College Dublin
Anthony Davies, Institute of Molecular Medicine, Trinity College, Dublin
Jason Swedlow, University of Dundee, Open Microscopy Environment
Nick Arini, product marketing manager Definiens
Kurt Herrenknecht, business development, Europe, Evotec
Ralph Garippa, research leader, Roche Discovery Technologies