Backup Compound Strategies: Best Practices for Reducing Phase II Risk

By Ken Rubenstein, PhD

SURVEY QUESTIONS

Objective: To illuminate current practices, plans, and views regarding compound backup procedures.

Participation: Individuals in industry and academic/nonprofit R&D involved with planning or executing compound backup plans.

1. Does your company have a clearly articulated back-up strategy?
 
2. What is your title and department?

3. Describe what influence the type of company may have on the back-up strategy
 
4. Describe what influence the indication may have on the back-up strategy
 
5. Describe what influence the specific compound or project may have on the back-up strategy
 
6. Describe the influence that the stage of development may have on the back-up strategy
 
7. Who has the greatest influence on the choice of a back-up strategy?
 
8. Does your company have a clearly articulated back-up strategy?
 
9. How consistent are back-up strategies within your company?
 
10. What role does under- or over-utilization of department resources play in back-up strategy decisions?
 
11. Please comment on timing issues relating to development of the lead and its back-ups
 
12. Select the comments that best describe your thinking about parked back-up compounds.
 
13. Does your company use business analysis techniques to determine your level of investment in a particular back-up strategy?
 
14. Are back-up molecules a significant factor in licensing or acquisition decisions?