Backup Compound Strategies: Best Practices for Reducing Phase II Risk

By Ken Rubenstein, PhD

TABLES

Table 1.1. Probabilities of Various Outcomes for 2 Backup Strategies

FIGURES

Figure 6.1. Respondents by Sector
Figure 6.2. Respondents by Position
Figure 6.3. Influence of Company Type on Backup Strategy
Figure 6.4. Influence of a Compound’s Indication on Backup Strategy
Figure 6.5. Influence of a Specific Compound/Project on Backup Strategy
Figure 6.6. Influence of Stage of Development on Backup Strategy
Figure 6.7. Managers’/Departments’ Influence on Choice of Backup Strategy
Figure 6.8. Evaluation of Company Backup Strategy
Figure 6.9. Consistency of Company Backup Strategies
Figure 6.10. Effects of Utilization/Underutilization of Department Resources in Backup Strategy Decisions
Figure 6.11. Timing of Work on Backup Compounds
Figure 6.12. Attitude Toward Parked Backup Compounds
Figure 6.13. Use of Business Analysis Techniques to Determine Investment in Backup Strategies
Figure 6.14. Backup Strategies as a Factor in Licensing or Acquisition Decisions

APPENDIX FIGURES

Figure 1A. TIP Algorithm Engine
Figure 2A. Possible Target Liability and New Ligand Opportunity
Figure 3A. Identifying “Off-Target” Opportunities and Liabilities (COX-2)
Figure 4A. Identifying Potential “Off-Target” Liabilities (Statins)
Figure 5A. Virtual Target Screening Example—Statins: Searching for Off-Targets to Explain Their Adverse Effects
Figure 6A. Virtual Target Screening Example—Statins: Searching for Off-Targets to Explain Their Pleiotropic Effects
Figure 7A. PXR: Promiscuous Ligand-Binding Site
Figure 8A. Off-Target Opportunities
Figure 9A. Nonobvious Me-Too’s
Figure 10A. ChIP-ing Toward Me-Too’s