Length:
146 pages

Date Published: 
October 2010

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Next-Generation Sequencing Technologies: Applications and Markets Report - Table of Contents

Author: Ken Rubenstein, PhD

EXECUTIVE SUMMARYEvolution of Next-Generation Sequencing
Basic Research
Applied Research
Market-Related Issues
Summary of Survey Results
Conclusions and Trends

CHAPTER 1
INTRODUCTION
Scope and Nature of the Report

CHAPTER 2
EVOLUTION OF NEXT-GENERATION SEQUENCING APPLICATIONS
2.1. The Human Genome Project
2.2. The Path to Current Next-Generation Sequencing Applications
2.3. Rise of the Personalized Medicine Paradigm
 

CHAPTER 3
BASIC RESEARCH
3.1. Epigenetics
Methylation
3.2. ChIP-Seq
3.3. RNA-seq
3.4. Exome Sequencing
3.5. Immunogenetics
3.6. Disease Mechanisms
Cancer 26
Neurological and Psychiatric Diseases
Infectious Diseases
3.7. Metagenomics
3.8. Evolution
3.9. Other
 

CHAPTER 4
APPLIED RESEARCH
4.1. Diagnostics
Cancer
Epigenetics and Cancer Diagnostics
Personal Genomics and Disease Prediction
Aneuploidy Detection
Carrier Screening
Other Diagnostic Activity
4.2. Drug Discovery
4.3. Agriculture and Animal Genomics

Plant
Animal
4.4. NGS-Related Consortia and Collaborative Projects  

CHAPTER 5
MARKET-RELATED ISSUES
5.1. User Survey Results
5.2. Next-Gen Sequencing Market Size, Character, and Growth
5.3. Translation to Diagnostics
5.4. Next-Gen Sequencing vs. the Microarray Market
5.5. The Controversial Personal Genomics Market
5.6. Exome vs. Whole Genome Sequencing
 

CHAPTER 6
CONCLUSIONS AND TRENDS
6.1. Personal Genomics
6.2. Translational Prospects
6.3. Survey Conclusions
 

CHAPTER 7 
EXPERT INTERVIEWS
7.1. Elaine Mardis, PhD, Co-Director, Director of Technology Development, The Genome Center at Washington University, St. Louis, MO
7.2. Eric Schadt, PhD, Chief Scientific Officer, Pacific Biosciences, Menlo Park, CA
7.3. Muin J. Khoury, MD, PhD, Director, Office of Public Health Genomics, Centers for Disease Control and Prevention (CDC), Atlanta, GA
7.4. Pharmaceutical Executive, Applied Genomics, Huntsville, AL
7.5. Stephan Züchner, MD, Associate Professor, Department of Human Genetics, Director, Center for Human Molecular Genomics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL
7.6. Steve S. Sommer, MD, PhD, Founder and President, MEDomics, Azusa, CA
 

REFERENCES  

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