Length 
130 pages

Date published 
February 2008

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Epigenetics Table of Contents

 

Epigenetics: Technologies, Applications, and the Commercial Landscape

Author: Leslie A. Pray, PhD

TABLE OF CONTENTS

Chapter 1
EPIGENETICS TODAY
      1.1 What Epigenetics is All About
            Epigenetics Defined
            Current and Potential Commercial Applications
      1.2. DNA Methylation and Histone Modifications: Focus of This Report
      1.3. The Etiology of Cancer: From a Mutational to Epigenetic Understanding
            Cancer as a Mutational Disease
            An Epigenetic Approach to Cancer Etiology
      1.4. The Epigenetics of Noncancerous Diseases
            Rett Syndrome
            Schizophrenia
            Alzheimer’s Disease

Chapter 2
DNA METHYLATION BIOMARKERS AND TECHNOLOGY: THE RACE IS ON
      2.1. The Mechanisms of Epigenetics
            A Focus on DNA Methylation
            Histone Modifications as Biomarkers: A Field in its Infancy
      2.2. The Power of DNA Methylation: Biomarker or Bust
            Clinical Applications of Methylation Diagnostics
            Major Challenges to Realizing the Potential of Epigenetic Diagnostics: Clinical Validation, Economic
            Validation and Provider Education
            Three Major Challenges to the Market Success of Epigenetic Diagnostics
      2.3. Homebrew Methylation Testing
      2.4. Epigenetic Diagnostic Companies
            Epigenomics
            OncoMethylome Sciences
            Orion Genomics
                  Interview with Cathy-Lofton Day, PhD
                 Vice President of Molecular Biology, Diagnostics
                 Epigenomics
      2.5. DNA Methylation Technology
            Gene-by-Gene Technologies: The Bisulfite Revolution and Beyond
      2.6. The Future is Genomewide
            DNA Microarrays
            High-Throughput Sequencing
            ChIP-on-chip and ChIP-Seq: Frontrunner Epigenomic Technologies
                  Interview with Jeff Falk, PhD
                  Director of Technology and Business Applications
                 Aviva Systems Biology
      2.7. DNA Methylation Research Prep Kits and Service Contracts: Making It Easy
            Companies Who Supply Kits
                  QIAGEN
                  Zymo Research
                  BioChain
                  Human Genetic Signatures
                  Millipore
                  Sigma-Aldrich
                  Panomics
                  Invitrogen
            Companies and Contract Services
                  Interview with Christopher Adams, PhD
                 Research Area Manager, Division of Epigenetic
                 Invitrogen

Chapter 3
EPIGENETIC DRUGS: THE RACE TO REVERSE SILENCING
      3.1. The Dynamic Nature of the Epigenome
      3.2. Demethylating Agents
           Only 2 FDA-Approved Agents
                 Vidaza
                 Dacogen
           Major Advantages and Disadvantages of Demethylating Drugs
      3.3 Histone Modifications: Using Drugs to Restore Acetylation
      3.4. Combination Therapy: Epigenetic Drugs Make Good Partners
           Interview with Donald F. Corcoran
           President and CEO
           MethylGene

Chapter 4
The Business of Epigenetics
      4.1. What is Driving Industry Interest in Epigenetics?
            New Knowledge
            New Technology
            Dry Pipelines
            Human Disease and Suffering
      4.2. The "Epigenetics Industry"
            Diagnostics
            Therapeutics
            Research Tools
      4.3. Industry Snapshot #1: Recent Major Business Deals
      4.4. Industry Snapshot #2: Recent Patent Applications Related to Epigenetics

Appendix
      Insight Pharma Reports – Epigenetics Survey – January 2008

References
Company Index with Web Addresses