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130 pages

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February 2008

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Epigenetics Survey Questions

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Epigenetics: Technologies, Applications, and the Commercial Landscape

Author: Leslie A. Pray, PhD

Insight Pharma Reports – Epigenetics Survey – January 2008

Objective: To illuminate trends, current practices, and views about epigenetics-based research and development. Participation: Individuals in life science R&D whose work involves epigenetics R&D.

  1. Please classify your organization.
  2. What is your title?
  3. Under what functional area do your responsibilities fall?
  4. When did your organization become involved with epigenetics-based applications (or, if the sole focus of your organization is epigenetics, when was your organization founded)?
  5. About what percentage of your organization’s research and/or development efforts revolve around epigenetics?
  6. Will your organization be expanding its epigenetics-based research or development efforts in the near future?
  7. If your organization conducts work relevant to epigenetic biomarker discovery or development, which of the following is your primary involvement?
  8. On what disease area(s) does your organization focus?
  9. What type of epigenetic modification/information is your primary focus?
  10. If your organization is involved with epigenetic profiling, which of the following is your primary application?
  11. If your organization conducts work relevant to DNA methylation biomarker discovery or development, which of the following best describes how you analyze methylation distribution?
  12. Does your organization use any of these technologies in its epigenetics-related research or product development?
  13. If your work involves DNA methylation or histone modification analysis, do you use a high-throughput technology?
  14. Is there any particular DNA methylation or histone modification analysis technology or technologies (other than or in addition to bisulfate conversion) that you think will emerge as the technology of choice for research purposes in the next 5 years?
  15. If you answered "yes" to the previous question, please indicate what technology or technologies.
  16. Is there any particular DNA methylation or histone modification analysis technology that you think will emerge as the technology of choice for clinical purposes in the next 5 years?
  17. If you answered "yes" to the previous question, please indicate which technology or technologies.
  18. Which of the following two do you think will be the greater contributor to growth of the epigenetics market space over the next 5 to 10 years?
  19. Which TWO of the following categories of next-generation technologies do you think have the greatest potential to dramatically enhance the commercial availability of epigenetic products over the next 5 to 10 years?
  20. Which of the following applications do you think will benefit the most, within the next 1 to 5 years, from continuing advances in epigenetic research and knowledge?
  21. Which of the following applications do you think will benefit the most, in 5 to 15 years, from continuing advances in epigenetic research and knowledge?
  22. Given that the basic science of epigenetics is growing at such a rapid pace, do you think the field will encounter "the valley of death" - a growing gap between basic research and the real-world application of that research?