1. Introduction
1.1 Related Reports 3
1.2 Upcoming Related Reports 4

2. Executive Summary 8
2.1 KOL Insight 6
2.2 GlobalData Insight 10

3. Research Panel Composition 14
3.1 5EU 15
3.2 US 16

4. Results and Implications 17
4.1 Future Use of Immunotherapy 18
4.1.1 Patterns in Unmet Needs 19
4.1.2 Clinical Potential of I-O in Oncology 22
4.1.3 Optimal Place for I-O in Treatment Algorithms 24
4.2 Challenges in I-O Trial Design 26
4.2.1 Predictive Biomarkers 30
4.2.2 Clinically Relevant Endpoints 35
4.2.3 Study Recruitment 38
4.2.4 Single-Arm Studies for Regulatory Approval 40
4.3 I-O Approaches and Combination Strategies 44
4.3.1 Potential of I-O Combinations 45
4.3.2 Potential of Novel Agents by Mechanism of Action 51

5. Appendix 54
5.1 Methodology 55
5.2 About the Authors 56
5.3 About GlobalData 58
5.4 Contact Us 59
5.5 Disclaimer 60