Medicinal Chemistry Approaches to Overcome Antibiotic Resistance, Volume 51,the latest release in the Annual Reports in Medicinal Chemistry series, provides timely and critical reviews of important topics in medicinal chemistry, with an emphasis on emerging topics in the biological sciences that are expected to provide the basis for entirely new future therapies. Topics of note in this release include, but are not limited to, Targeting Human onchocerciasis: recent advances beyond Ivermectin, Leishmania species, Trypanosoma brucei and Trypanosoma cruzi, Ebola, and Crystallographic approaches in NTDs drug discovery.